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bZIP domain

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  1. BZIP domain
BZIP domain
Protein domain
SymbolbZIP_1
PfamPF00170
InterProIPR011616
PROSITEPDOC00036
SCOP21ysa / SCOPe / SUPFAM
CDDcd14686
Membranome235

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as and . Proteins containing this domain are .

leucine zipper
arginine
lysine
transcription factors
1
2

This article is about the protein domain. For the compression algorithm, see Bzip2.

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Contents
  • (Top)
  • bZIP transcription factors
  • bZIP domain containing proteins
  • Human proteins containing this domain
  • References
  • External links
  • Recent changes
  • Rabbit hole
Contents
Contents7 sections
  • (Top)
  • bZIP transcription factors
  • bZIP domain containing proteins
  • Human proteins containing this domain
  • References
  • External links
  • Recent changes
  • Rabbit hole
Study aids for BZIP domain

Terminology

Basic Leucine Zipper Domain
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins.

Terms the article defines in bold, quoted in context.

Categories:
  • Protein domains
  • DNA-binding proteins

253 words · 9 references · revision 1382120867 · CC BY-SA 4.0

General
  • Recent changes
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This article
Reading time
3 min
Topic
Biology
Quality
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Views
116 in 14 days
Last edited
26 Oct 2026

Key concepts

  • DNA1
  • Leucine zipper1
  • Arginine1
  • Lysine1
  • Transcription factors1
  • Most recent common ancestor1
  • C-jun2
  • JUNB2
  • NFE2L22
  • AP-1 (transcription factor)1

The articles this one links to most, weighted towards the introduction.

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bZIP transcription factors

bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs.3 An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants.4 Interactions between bZIP transcription factors are numerous and complex 563 and play important roles in cancer development7 in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues,8 factors affecting reproductive functions,9 and several other phenomena that affect human health.

bZIP domain containing proteins

  • AP-1 fos/jun heterodimer that forms a transcription factor
  • Jun-B transcription factor
  • CREB cAMP response element transcription factor
  • OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea mays) kernels
  • NFE2L2 or Nrf2
  • Bzip Maf transcription factors

Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; ; ; ; ; ; ; ; ; ; ; ; ; SNFT;

References

  1. 1Ellenberger T (1994). "Getting a grip in DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains". Curr. Opin. Struct. Biol. 4 (1): 12–21. doi:10.1016/S0959-440X(94)90054-X.
  2. 2Hurst HC (1995). "Transcription factors 1: bZIP proteins". Protein Profile. 2 (2): 101–68. PMID 7780801.
  3. 3Amoutzias, Grigoris D.; Robertson, David L.; Van de Peer, Yves; Oliver, Stephen G. (2008-05-01). "Choose your partners: dimerization in eukaryotic transcription factors". Trends in Biochemical Sciences. 33 (5): 220–229. doi:10.1016/j.tibs.2008.02.002. ISSN 0968-0004. PMID 18406148.
  4. 4Corrêa LG, Riaño-Pachón DM, Schrago CG, dos Santos RV, Mueller-Roeber B, Vincentz M (2008). Shiu SH (ed.). . . (8) e2944. :. :. . .

External links

  • bZIP domain entry in the SMART database
  • bZIP family Archived 2013-12-07 at the Wayback Machine at PlantTFDB: Plant Transcription Factor Database
  • Plant bZIP transcription factors Archived 2012-03-20 at the Wayback Machine
JUNB
JUND
MAFA
MAFB
MAFF
MAFG
NRL
C-MAF
MAFK
NFE2
NFE2L2
NFE2L3
XBP1
"The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes"
PLOS ONE
3
Bibcode
2008PLoSO...3.2944C
doi
10.1371/journal.pone.0002944
PMC
2492810
PMID
18698409
  • 5Vinson, Charles; Acharya, Asha; Taparowsky, Elizabeth J. (2006-01-01). "Deciphering B-ZIP transcription factor interactions in vitro and in vivo". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1759 (1–2): 4–12. doi:10.1016/j.bbaexp.2005.12.005. ISSN 0006-3002. PMID 16580748.
  • 6Newman, John R. S.; Keating, Amy E. (2003-06-27). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–2101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. ISSN 1095-9203. PMID 12805554. S2CID 36715183.
  • 7Vlahopoulos SA, Logotheti S, Mikas D, Giarika A, Gorgoulis V, Zoumpourlis V (April 2008). "The role of ATF-2 in oncogenesis". BioEssays. 30 (4): 314–27. doi:10.1002/bies.20734. hdl:10442/7311. PMID 18348191. S2CID 678541.
  • 8Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM (January 2002). "Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family". Mol. Endocrinol. 16 (1): 184–99. doi:10.1210/mend.16.1.0759. PMID 11773448.
  • 9Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS (May 1999). "Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun". Endocrinology. 140 (5): 2268–79. doi:10.1210/endo.140.5.6710. PMID 10218980.
    • Created
    8 Sept 2005
    History
    110 edits
    77 contributors
    1 edit in the last 30 days
    Last edited
    26 Oct 2026

    110 revisions in total · 77 contributors · +15 / 0 bytes across 1 edits by 1 contributor in the last 30 days

    1. 26 Oct 2026, 18:58 UTCPabnaum§ Human proteins containing this domain Add link+15diff
    2. 4 May 2026, 14:27 UTCIdiosyncraticLawyermRemoving illicit template parameter−12diff
    3. 6 Apr 2026, 05:59 UTCOAbotmOpen access bot: hdl updated in citation with #oabot.+39diff
    4. 29 Jan 2026, 22:53 UTCInternetArchiveBotRescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.5) (Whoop whoop pull up - 28482+132diff
    5. 17 Oct 2025, 13:13 UTCMonkbotm§ bZIP transcription factors Monkbot/task 21: Replace page(s) with article-number;+9diff
    6. 13 Mar 2024, 00:42 UTCInternetowyGołąb§ Human proteins containing this domain link as per https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAF (uppercase vs typical c-Xyz for protooncogenes)+11diff
    7. 8 Nov 2023, 11:34 UTCOAbotmOpen access bot: doi updated in citation with #oabot.+16diff
    8. 20 Jul 2023, 02:30 UTCTeaktl17m§ bZIP domain containing proteins +wl+4diff

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    Created
    8 Sept 2005
    History
    110 edits
    77 contributors
    1 edit in the last 30 days
    Last edited
    26 Oct 2026

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