 Class of enzymes important in regulating DNA transcription | |
| EC no. | 3.5.1.98 |
|---|---|
| CAS no. | 9076-57-7 |
| BRENDA | enzyme data |
| ExPASy | NiceZyme view |
| KEGG | enzyme entry |
| MetaCyc | metabolic pathway |
| Rhea | reactions |
| PDB structures | RCSB PDB |
| Gene Ontology | AmiGO / QuickGO |
|---|
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins.2 HDACs allow histones to wrap the DNA more tightly.3 This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. HDAC's action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.4 In general, they suppress gene expression.5
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