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InterPro

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10 Nov 2026
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  1. InterPro
InterPro
Database of protein families, domains and functional sites
DescriptionInterPro functionally analyzes protein sequences and classifies them into protein families while predicting the presence of domains and functional sites.
Research centerEMBL
LaboratoryEuropean Bioinformatics Institute
Primary citationThe InterPro protein families and domains database: 20 years on1
Release date1999
Websitewww.ebi.ac.uk/interpro/
Download URLftp.ebi.ac.uk/pub/databases/interpro/
Data release frequency8-weekly
Version97.0 (9 November 2023 (2023-11-09))

InterPro is a database of , and in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterise them.

protein families
protein domains
functional sites
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3
4

The contents of InterPro consist of diagnostic signatures and the proteins that they significantly match. The signatures consist of models (simple types, such as regular expressions or more complex ones, such as Hidden Markov models) which describe protein families, domains or sites. Unknown sequences are searched to create homology models. Each of the member databases of InterPro contributes towards a different niche, from very high-level, structure-based classifications (SUPERFAMILY and CATH-Gene3D) through to quite specific sub-family classifications (PRINTS and PANTHER).

InterPro's intention is to provide a one-stop-shop for protein classification, where all the signatures produced by the different member databases are placed into entries within the InterPro database. Signatures which represent equivalent domains, sites or families are put into the same entry and entries can also be related to one another. Additional information such as a description, consistent names and Gene Ontology (GO) terms are associated with each entry, where possible.

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General
  • Recent changes
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This article
Reading time
7 min
Topic
Mathematics
Quality
B-class
Views
99 in 14 days
Last edited
10 Nov 2026
Print/export
  • Printable version
In other projects
  • Wikidata item
Last edited
10 Nov 2026